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KMID : 0383820080650040285
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Tuberculosis and Respiratory Diseases
2008 Volume.65 No. 4 p.285 ~ p.291
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Polymorphisms in the SERPINA1 Gene and the Risk of Chronic Obstructive Pulmonary Disease in a Korean Population
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Cha Seung-Ick
Choi Jin-Eun
Lee Jong-Myung
You Seung-Soo
Kim Chang-Ho
Lee Won-Kee
Jung Tae-Hoon
Kim Nung-Soo
Park Jae-Yong
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Abstract
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Background: We conducted a case-control study to evaluate the potential association between SERPINA1 genotypes (M1Val, M1Ala, S, and Z) and the risk COPD.
Methods: The study population consisted of 93 patients with COPD and 112 healthy controls. The polymerase chain reaction and restriction fragment length polymorphism for detecting the SERPINA1 variants.
Results: The M2 allele of the SERPINA1 gene was significantly associated with the risk of COPD in Koreans. The effect of the M2 allele on the risk of COPD was more pronounced in the subgroup＜64 years.
Conclusion: These results suggest that SERPINA1 polymorphisms may contribute to a genetic predisposition for COPD. However, additional studies with larger sample sizes are required to confirm our findings.
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KEYWORD
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SERPINA1 gene, Polymorphism, COPD
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